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Are Coursera courses still free At Class Central, we get that question so often that I wrote a guide to answer it. Generally speaking, Coursera courses are free to audit, but if you want to access graded assignments or earn a Course Certificate, you will need to pay. This change was first announced in October 2015, and went live in January 2016.
Access is one thing, but a complete course experience is another. we need to distinguish between a course like CS50 on Edx, which offers a complete experience for free, vs many courses on Coursera (or lately Edx), that allow access to videos but not much else. The AI for Medicine, for e.g. offers an audit experience, but also hides some course exercises, quizzes etc.
As we note in the article, the certificates are paid but all the contents of the course including graded assignments are free. For other Coursera courses, the graded assignments are also behind the certificate paywall.
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An intricate network of crevices adorns the skin surface of the African bush elephant, Loxodonta africana. These micrometre-wide channels enhance the effectiveness of thermal regulation (by water retention) as well as protection against parasites and intense solar radiation (by mud adherence). While the adaptive value of these structures is well established, their morphological characterisation and generative mechanism are unknown. Using microscopy, computed tomography and a custom physics-based lattice model, we show that African elephant skin channels are fractures of the animal brittle and desquamation-deficient skin outermost layer. We suggest that the progressive thickening of the hyperkeratinised stratum corneum causes its fracture due to local bending mechanical stress in the troughs of a lattice of skin millimetric elevations. The African elephant skin channels are therefore generated by thickening of a brittle material on a locally-curved substrate rather than by a canonical tensile cracking process caused by frustrated shrinkage.
Next, we investigate the nature of these crevices. Our light and electron microscopic analyses reveal that each channel in the African elephant skin is a sharp discontinuity in the stratum corneum (Fig. 2a, b). The keratin sheets of the latter display a clear alignment on both sides of the discontinuity, suggesting that, prior to the formation of the fissure, the stratum corneum was continuous in the trough, as observed in uncracked regions of the skin (Fig. 2c). Our proposition that channels in the African elephant skin correspond to physical cracking of the outermost highly keratinised part of the epidermis is strengthened by a diverse body of additional experimental observations that include: (i) the detachment of the stratum corneum into units delimited by channels when it is mechanically extracted from the rest of the skin (Supplementary Movies 3 and 4), (ii) the in vivo reorganisation of the network of channels following the regrowth of the stratum corneum after its ablation (Supplementary Figs. 1, 2), (iii) the heterogeneous trough width distribution visible in some samples (see Supplementary Text and Supplementary Fig. 3), and (iv) the presence of papillae but the absence of crevices on the skin of a newborn animal (see Supplementary Text and Supplementary Fig. 4). All these observations are compatible with our initial hypothesis, namely that the channels visible on the skin of the African bush elephant are physical cracks of the stratum corneum.
Finally, our numerical model recapitulates the rare occurrence of side cracks (Fig. 5e, f), as well as the alignment of the stratum corneum sheets (Fig. 5g, h) and the lack of recoil between the two sides of the fracture (i.e. the width of the crack is of the order of the mesh spacing, see Fig. 5i), and suggests that the clumping of papillae (occurring in some body regions such as the forehead) is caused by increased thickness of the stratum corneum (see Supplementary Text and Supplementary Fig. 20). In all cases, we found the data from the real skin to be consistent with the proposed hypothesis of a cracking process generated by bending stress, although we can not rule out the possible existence of spatial anisotropy of the stratum corneum (causing differences in its mechanical properties on papillae versus troughs) that would confine the cracks to the troughs.
Note that the process by which the papillae are patterned in the embryo is unknown. Further studies are also warranted to assess whether the lack of a cracking pattern on the skin of the Asian elephant is due to reduced orthokeratosis (in comparison to the African elephant), preventing the stratum corneum either from drying sufficiently to break in a brittle fashion or from reaching large enough thickness to generate material failure bending stresses in the troughs.
In this article we introduce the software SimKinet, a free tool specifically designed to solve systems of differential equations without any programming skill. The underlying method is the so-called Network Simulation Method, which designs and solves an electrical network equivalent to the mathematical problem. SimKinet is versatile, fast, presenting a real user-friendly interface, and can be employed for both educational and researching purposes. It is particularly useful in the first courses of different scientific degrees, mainly Chemistry and Physics, especially when facing non-analytic or complex-dynamics problems. Moreover, SimKinet would help students to understand fundamental concepts, being an opportunity to improve instruction in Chemistry, Mathematics, Physics and other Sciences courses, with no need of advanced knowledge in differential equations. The potency of SimKinet is demonstrated via two applications in chemical kinetics: the photochemical destruction of stratospheric ozone and the chaotic dynamics of the peroxidase-oxidase reaction.
Citation: Caravaca M, Sanchez-Andrada P, Soto-Meca A (2019) SimKinet: A free educational tool based on an electrical analogy to solve chemical kinetic equations. PLoS ONE 14(3): e0213302.
In this work we introduce SimKinet along with some interesting applications in chemical kinetics, showing its strength for solving advanced numerical problems. Although a wide spectrum of software designed to solve kinetic chemical equations is available, the most recognized among them are not free [27,28], while others present restrictions in the timestepping [29,30], considered as fixed, or demand additional computing skills [31]. Due to its simple handling and adaptative timestepping, SimKinet becomes an outstanding alternative. 153554b96e
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